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Clinical Information

Patient-specific data obtained outside the office has been a very powerful tool in treatment and decision-making for diagnosis, monitoring, and management of chronic conditions for years in other fields. Cardiovascular health and diabetes sets a prime example of the impact that out-of-office blood pressure and glucose measurements can have on improving patient care.

 

Intraocular pressure (IOP) is currently monitored in-office during isolated daytime measurements. Current standard of care in glaucoma management includes measurement of IOP every few months, between the hours of 8AM and 5PM, even for patients with severe disease. Treatment decisions are often based on these individual snapshots in time of a single IOP reading. However, we have long known and recognized that critical values of IOP fluctuate throughout day and night (nyctohemeral fluctuation), day-to-day (short-term), and over months to years (long-term). Knowing that IOP, as the primary modifiable risk factor for glaucoma disease progression, can fluctuate has motivated development of better ways of capturing diurnal and nocturnal IOP variability.
Studies have shown that diurnal and nocturnal IOP rhythms fluctuate, with spikes often occurring outside of office hours. In studies of IOP measured around-the-clock in hundreds of patients, peak IOP can occur morning or night.1-3 Missing these peaks in measurements can result in misdiagnosis and under-treatment. For example, in a cohort of patients with a diagnosis of normotension glaucoma, 5.3% were found to have IOP greater than 20 mm Hg on 24-hour recordings.4 In addition to spikes in IOP, wide fluctuations in IOP have also been theorized to contribute to progression of glaucoma.5

 

Factors modulating fluctuations in IOP are theorized to include such things as position, exercise, episcleral venous pressure, hormone levels, and nitric oxide production. IOP generally tends to be higher in the supine position, but can be potentially modulated by other systemic conditions such as nocturnal hypotension and sleep apnea.6 Kim et al found that patients with normotensive glaucoma have higher fluctuations in nocturnal IOP and spend more time during sleep in lateral decubitus position.7 Studies have also suggested a correlation between cortisol and IOP in patients faced with psychological stress or relaxation, although a correlation between IOP and midnight plasma cortisol was not supported in a study of IOP in patients with Cushing Syndrome.8-10 Variations in many of these factors most likely contribute to diurnal and nocturnal rhythms in IOP, aqueous production and outflow, and possibly contribute to optic nerve health.
Devices have been developed for home IOP monitoring, allowing for tracking of IOP at all hours. Rebound tonometry has become an accepted non-contact means of measuring IOP in our offices; the iCare tonometers have been found to have fairly accurate reproducibility to Goldmann with a strong intraclass correlation coefficient.12,13 Subsequently, the iCare HOME tonometer was FDA-cleared for use in 2017 and indicated as an adjunct to routine clinical IOP monitoring for patients’ self-use at home with a doctor’s prescription.14iCare HOME measurements have been shown to agree with in-office measurements on the same eyes.15,16

 

We believe home monitoring can be an important tool to detect variations in IOP that might be occurring despite in-office measurements that are consistently at goal. In a recent case report, Rojas et al presented two patients with glaucomatous progression despite controlled in-office IOPs.17 With measurements at home, patients were found to have IOPs ranging from 1.4 to 2.6-fold higher than peak in office, thus necessitating immediate changes in treatment. We have had similar cases in our clinic; for example, a normal tension glaucoma patient with severe visual field constriction- who’s in-clinic IOP measurements were “controlled” in the low teens. Using the iCare Home, he was found to have IOP spikes during the night into the high 20s even on maximum medication, thus necessitating surgery. We have discovered that self-tonometry can easily be performed at home after a short training session and thus be used to check IOP over several days to weeks and even over a 24-hour period. It is for these reasons that we started MyEYES, to give the patient and their physicians the IOP data that could help impact medical glaucoma management. (Excerpt from Levin, Vezina, Wirostko. Ophthalmology Glaucoma in press 2021)

References:

 

  1. Jonas JB, Budde W, Stroux A, Oberacher-Velten IM, Jünemann A. Single intraocular pressure measurements and diurnal intraocular pressure profiles. Am J Ophthalmol. 2005;139(6):1136-1137. Doi:10.1016/j.ajo.2004.12.012
  2. Tajunisah I, Reddy SC, Fathilah J. Diurnal variation of intraocular pressure in suspected glaucoma patients and their outcome. Graefes Arch Clin Exp Ophthalmol. 2007;245(12):1851-1857. Doi:10.1007/s00417-007-0681-7
  3. Tan S, Baig N, Hansapinyo L, Jhanji V, Wei S, Tham CC. Comparison of self-measured diurnal intraocular pressure profiles using rebound tonometry between primary angle closure glaucoma and primary open angle glaucoma patients. PloS One. 2017;12(3). Doi:10.1371/journal.pone.0173905
  4. Hasegawa K, Ishida K, Sawada A, Kawase K, Yamamoto T. Diurnal variation of intraocular pressure in suspected normal-tension glaucoma. Jpn J Ophthalmol. 2006;50(5):449-454. Doi:10.1007/s10384-006-0343-z
  5. Gao F, Miller JP, Miglior S, et al. A Joint Model for Prognostic Effect of Biomarker Variability on Outcomes: long-term intraocular pressure (IOP) fluctuation on the risk of developing primary open-angle glaucoma (POAG). JP J Biostat. 2011;5(2):73-96.
  6. Gautam N, Kaur S, Kaushik S, Raj S, Pandav SS. Postural and diurnal fluctuations in intraocular pressure across the spectrum of glaucoma. British Journal of Ophthalmology. 2016;100(4):537-541. Doi:10.1136/bjophthalmol-2015-306861
  7. Kim YW, Kim J-S, Lee SY, et al. Twenty-four-Hour Intraocular Pressure-Related Patterns from Contact Lens Sensors in Normal-Tension Glaucoma and Healthy Eyes: The Exploring Nyctohemeral Intraocular pressure related pattern for Glaucoma Management (ENIGMA) Study. Ophthalmology. 2020;127(11):1487-1497. Doi:10.1016/j.ophtha.2020.05.010
  8. Mishra P, Singh AP, Kanaujia V, et al. Intraocular pressure and its correlation with midnight plasma cortisol level in Cushing’s disease and other endogenous Cushing’s syndrome. Indian J Ophthalmol. 2017;65(9):826-829. doi:10.4103/ijo.IJO_684_15
  9. Abe RY, Silva TC, Dantas I, et al. Can Psychologic Stress Elevate Intraocular Pressure in Healthy Individuals? Ophthalmol Glaucoma. 2020;3(6):426-433. doi:10.1016/j.ogla.2020.06.011
  10. Dada T, Mittal D, Mohanty K, et al. Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma Randomized Controlled Trial. J Glaucoma. 2018;27(12):1061-1067. doi:10.1097/IJG.0000000000001088
  11. Wilensky JT. Diurnal Variations in Intraocular Pressure. Trans Am Ophthalmol Soc. 1991;89:757-90.
  12. Brusini P, Salvetat ML, Zeppieri M, Tosoni C, Parisi L. Comparison of Icare Tonometer with Goldmann Applanation Tonometer in Glaucoma Patients. Journal of Glaucoma. 2006;15(3):213-217. Doi:10.1097/01.ijg.0000212208.87523.66
  13. Chen M, Zhang L, Xu J, et al. Comparability of three intraocular pressure measurement: iCare pro rebound, non-contact and Goldmann applanation tonometry in different IOP group. BMC Ophthalmology. 2019;19(1):225. Doi:10.1186/s12886-019-1236-5
  14. U.S. Food and Drug Administration, Icare Home tonometer K163343 approval letter, February 6, 2017. Retrieved January 18, 2021 from https://www.accessdata.fda.gov/cdrh_docs/pdf16/K163343.pdf
  15. Tatham AJ, Young SL, Chew E, Brown L. A Comparison of Short-Term Intraocular Pressure Fluctuation with Office-Based and Home Tonometry. Ophthalmology Glaucoma. Published online August 17, 2020. Doi:10.1016/j.ogla.2020.08.005
  16. Mudie LI, LaBarre S, Varadaraj V, et al. The Icare HOME (TA022) Study: Performance of an Intraocular Pressure Measuring Device for Self-Tonometry by Glaucoma Patients. Ophthalmology. 2016;123(8):1675-1684. Doi:10.1016/j.ophtha.2016.04.044
  17. Rojas CD, Reed DM, Moroi SE. Usefulness of Icare Home in Telemedicine Workflow to Detect Real-World Intraocular Pressure Response to Glaucoma Medication Change. Ophthalmology Glaucoma. 2020;3(5):403-405. Doi:10.1016/j.ogla.2020.04.017

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